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DiagBox V5.02.rarJohanna Konta is looking ahead to her second major tournament of the season after receiving a wildcard into the Shenzhen Open, but she must qualify for the semi-finals if she is to earn a place in the season-ending WTA Finals.

The Briton and US Open champion booked her place in the event by beating Japanese third seed Kurumi Nara in the opening round, but she has never played in China as she must first secure a place in one of the two qualification rounds on 22nd-24th November.

The 11th seed will be seeded next to her compatriot Laura Robson, who won the event in 2015 and has recorded top-10 wins on the WTA since 2013 when she became the first British winner since Jo Durie in 1997, and is the number one seed in Wuhan.Correction of DNA double-strand breaks in somatic cells by co-expressing a donor template with the repair protein XRCC1.
Genomic insults inflicted on mammalian cells by ionizing radiation (IR) result in the induction of DNA double-strand breaks (DSB), which requires the coordinated action of multiple proteins involved in DSB repair. Disruption of this complex network results in genomic instability and tumorigenesis. Thus, the repair of radiation-induced DSBs is an important mechanism of radiotherapy. The efficacy of IR-based therapies is limited by the inability of mammalian cells to repair the majority of DSBs and the fact that normal tissues are more sensitive to the damaging effects of IR than tumor cells. Furthermore, because IR-induced DSBs are difficult to repair correctly, somatic cells have a limited capacity to restart the damaged chromatid after a second round of cell division. We have developed an approach to increase the efficacy of IR-induced DSB repair in mammalian somatic cells by simultaneously co-expressing a donor template with the repair protein XRCC1. The repair efficacy was increased in HEK 293 cells by as much as 100-fold relative to cells expressing XRCC1 alone. Furthermore, the radiation resistance of these cells was increased by 80-fold in the presence of the donor template and


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