Mirrors Tamil Dubbed
mirrors tamil dubbedEffect of cyclic fatigue on the fracture strength of orthodontic brackets bonded to stainless steel and enamel.
Comparison of the fracture strength of orthodontic brackets bonded to stainless steel and enamel with and without a cyclic fatigue test. Brackets were bonded to an unpolished stainless steel surface and a polished enamel surface (n=10/group). Brackets were tested for fracture strength in a 1-hour, 50,000-cycle fatigue test immediately after bonding or after a 7-day water storage period. Strength data were analyzed with Student’s t-tests (pPositive and negative modulators of Epstein-Barr virus-encoded latent membrane protein 1 (EBV-LMP1).
The Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) is a pleiotropic signal transducer that modulates cellular gene transcription, mitotic progression, DNA replication and apoptosis. EBV-LMP1 activates the protein kinase c-Raf and the constitutive and inducible activator protein kinases PKC-alpha, PKC-beta1 and PKC-theta in lymphoid cells. LMP1 has been implicated in the pathogenesis of various human malignancies. Inhibition of LMP1 function in the EBV-infected cells represents a potential approach for the treatment of EBV-associated neoplasias. However, the cellular pathways by which LMP1 promote tumorigenesis remain elusive. We have recently demonstrated that LMP1 induces the phosphorylation of paxillin (S178/180) and that this phosphorylation leads to the downregulation of the adhesion activity of the molecule. The negative regulation of paxillin by EBV-LMP1 may be important for tumor cell invasion of
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